Jefferson has been the principal or co-founder of more than a dozen organizations and initiatives, most of which continue to live, thrive, and evolve. Most recently, Jefferson was the cofounder of Tryl.ai, a clinical research software startup that successfully sold to YPrime. He continues to work to help companies start, grow, and innovate.

Jefferson continues to help leaders and organizations get started, start again, and organize Innovation Networks to convene thought leaders and spark ideas.